微流控肺器官芯片是一种基于微流体学技术设计和制造的微型实验平台,用于模拟肺部的结构和功能。
它是由一系列微型通道、腔室和细胞培养膜组成的微型器官,可以模拟肺部的呼吸运动、氧气和二氧化碳的交换、免疫反应等生理和病理过程。
通过在芯片内引入不同类型的细胞、病毒、细菌和药物,可以实现对肺部疾病的模拟和药物筛选。
微流控肺器官芯片具有许多优点,如高可重复性、高可控性、高仿真性、易于操作和自动化等。
相比传统的细胞培养和动物试验,微流控肺器官芯片具有更高的准确性和可靠性,可以更好地模拟肺部的生理和病理情况。
因此,它可以为肺部疾病的研究、药物筛选和毒性评估提供高效、可靠的实验平台,有望成为肺部疾病治疗和药物研发的重要工具。
The human alveolus chip includes a hollow side channel, allowing the application of suction to the chip, imposing cyclic strain mimicking normal human respiratory movements (left image). A permeable membrane separates human alveolar cells in the upper channel from human vascular cells in the lower channel, enabling them to exchange molecular signals (right image).
The microfluidic lung organ chip is a miniature experimental platform based on microfluidics technology, designed to simulate physiological and pathological processes of the lungs. Experiments on this chip can be conducted through the following methods:
In summary, the microfluidic lung organ chip provides a highly realistic microenvironment for lung-related experiments in areas such as lung disease research, drug screening, and toxicity assessments.
The microfluidic lung organ chip is a novel platform for in vitro research on the physiological and pathological aspects of the lungs. It can simulate the structure and function of the lungs and is capable of high-throughput drug screening and disease modeling experiments. In recent years, research progress in microfluidic lung organ chips has been rapid, primarily encompassing the following aspects:
In the future, research on microfluidic lung organ chips will delve deeper, serving not only for fundamental scientific research but also for clinical applications such as lung cancer screening and treatment.
Here are translations of the provided text into English:
2. “Microfluidic lung models to study alveolar epithelial barrier function” (2020): This literature proposes a lung model manufactured using microfluidic technology to study the function and disruption of alveolar epithelial barriers, as well as the pathogenesis of lung diseases. This research provides new experimental methods for lung drug screening and treatment.
3. “Microfluidic Organ-on-a-Chip Models of Human Lung Cancer” (2019): This paper introduces a lung cancer organ chip manufactured using microfluidic technology, which can be used to study the pathogenesis and treatment of lung cancer. The chip can simulate processes such as the growth, migration, and drug sensitivity of lung cancer cells in the lung microenvironment.
4.“Development of a microfluidic chip for pulmonary drug screening using A549 lung cancer cells” (2020): This literature describes a microfluidic chip for lung cancer drug screening, manufactured using microfluidic technology. It is used to assess the sensitivity and drug resistance of A549 lung cancer cells. The chip can simulate processes such as drug metabolism and the growth and migration of tumor cells in the lung microenvironment.
These papers showcase the application prospects of microfluidic lung organ chips in the research and drug screening of lung diseases. By simulating the lung's microenvironment and physiological processes, microfluidic lung organ chips offer an efficient and reliable experimental platform for the treatment and drug development of lung diseases.
Product Code | Outline (mm) | Channel | Microporous membrane | Material | Price (CNY) | |||
Height (mm) | Width (mm) | Space (mm) | Thickness (um) | Hole diameter (um) | ||||
600001 | 30*15 | 0.5 | 1 | 0.2 | 25 | 8 | PDMS | 800 |
600002 | 30*15 | 0.5 | 1 | 0.5 | 25 | 8 | PDMS | 800 |
Dxfluidics is a specialized enterprise dedicated to customizing various microfluidic organ chips. With a highly skilled and experienced processing team, we offer one-stop organ chip processing services for our clients. The company is committed to providing high-quality, high-performance biochip products for the fields of biomedicine, biomedicine, bio-detection, cell culture, and more.
Let the flower of life bloom more beautifully, Dxfluidics microfluidic organ chips make miniature life experiments more precise!
DingXu (Suzhou) Microfluidics Technology Co., Ltd. is a high-tech enterprise dedicated to the field of microfluidics. We are committed to providing customers with comprehensive microfluidic solutions, including customized microfluidic chip development, surface modification, microfluidic chip processing equipment, and microfluidic instruments. Our team boasts extensive experience and technical expertise, continuously combining professional knowledge with innovative thinking to deliver high-quality solutions. We consistently prioritize customer-centric values, embrace self-challenges, and pursue excellence. Through professionalism, innovation, and collaboration, we aim to create greater value for our customers and contribute to a brighter future in the field of microfluidics.
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