Microfluidic intestinal organoids are microfluidic technology-based biochips that can be used to study intestinal physiology, pathological processes, and intestinal-microbial interactions.
It simulates the anatomy, physiological structure and function of the intestinal tract, allowing for long-term culture and simulation of the intestinal tract in vitro.
Microfluidic intestinal organ chips typically consist of microfluidic channels, intestinal epithelial cells, intestinal mucosal cells, intestinal flora, and fluid and gas channels.
Among them, microfluidic channels can simulate the structure and morphology of the intestine, intestinal epithelial and mucosal cells can simulate the physiological and pathological state of the intestine, and intestinal flora can simulate the composition and function of the intestinal microbial community.
Liquid and gas channels mimic the flow of substances in the intestines and the physiological environment within the intestines.
Microfluidic intestinal organ chips can be used to study intestinal absorption, secretion, peristalsis, inflammation, intestinal flora-host interactions, and metabolism of food additives and drugs.
It can provide more realistic intestinal models, reduce the use of animal experiments, and provide a more reliable platform for drug development and safety assessment.
The experimental methodology of microfluidic intestinal organ chips can be divided into the following steps:
The experimental methodology of microfluidic intestinal organoids can be adapted and optimized for specific research purposes and experimental designs.
Microfluidic intestinal organ chips are one of the research areas that have received extensive attention in recent years, and current research progress has focused on the following aspects:
There have been many research papers reporting the application of microfluidic intestinal organoids in the above fields, such as the use of microfluidic intestinal microarrays to assess the effect of dietary fiber on intestinal health, and the development of microfluidic intestinal microarrays for the study of the interactions between the intestinal flora and the host immune system.
With the continuous development and improvement of the technology, it is believed that the application of microfluidic intestinal organ chips in intestinal-related fields will be more and more promising.
Here are some recent research papers on microfluidic intestinal organ chips for your reference:
This paper reports an intestinal microarray system with flexible microfluidic channels for real-time monitoring of intestinal epithelial cell growth and membrane permeability, and for high-throughput screening of drug effects on intestinal epithelial cells.
In this paper, we report an intestinal microarray system for oral chemotherapeutic drugs that can mimic physiological and pathological states in the intestinal tract and can evaluate the absorption and metabolism processes of oral chemotherapeutic drugs, providing an efficient and reliable platform for the development and evaluation of oral chemotherapeutic drugs.
This paper reports a microfluidic gut microarray system for assessing the impact of probiotics on gut health that mimics microbial communities and metabolic processes in the gut and allows for real-time monitoring of the growth and function of intestinal epithelial cells.
These studies show that microfluidic intestinal organoids are a very promising technological platform for studying intestinal-related biological problems and drug discovery, and it is believed that more studies will emerge in the future.
Cell migration microarrays to study cell-to-cell interactions and the effects of perfusion versus diffusion-based, real-time analysis of experiments with all cell populations, Cell migration microarrays are designed to mimic the formation and transport of tight and gap junctions (e.g., the blood-brain barrier and other endothelial/tissue interfaces), and are available with a wide range of choices in channel sizes, tissue compartment sizes, and scaffolds, as well as barrier designs.
Slit Barrier: This device utilizes slits spaced at regular intervals to form a barrier area between the outer and inner chambers.
Available standard design parameters include:
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