The Electrophoresis Microfluidic Chip is an innovative bioanalytical tool that combines electrophoresis and microfluidic technologies.
Integrating the advantages of microfluidics, this technology utilizes micro-scale channels, electric fields, and highly flexible flow control to achieve efficient separation, detection, and analysis of biomolecules.
This article delves into the technical principles, application areas, advantages, challenges, and future prospects of CEMC.
I. Technical Principles:
The core principle of the Electrophoresis Microfluidic Chip lies in the fusion of electrophoresis and microfluidic technologies.
It employs microchannels, electrophoresis buffers, and detection systems for the efficient separation of biomolecules through the influence of electrophoresis buffers in microchannels, with the detection system facilitating real-time monitoring and recording of separated biomolecules.
The introduction of microfluidics makes electrophoretic separation more flexible, enabling high-throughput, high-resolution analysis.
Tiny channels reduce sample and reagent usage, increasing efficiency while also reducing analysis time.
This integrated design makes the electrophoretic microfluidic chip a powerful bioanalytical tool.
Application Areas：
Genetic Analysis: Widely used for DNA fragment separation, sequencing, and detection of gene mutations in genetic analysis.
Protein Analysis: Efficiently analyzes complex protein mixtures for quantitative purposes and mass spectrometry studies.
Biomarker Detection: Essential for detecting specific molecules in biological samples, such as cell markers, proteins, and nucleic acids, with significant implications for disease diagnosis and treatment monitoring.
Drug Screening: Applied in drug analysis and screening, assessing drug efficacy and toxicity by separating drugs and their metabolites in biological samples.
Environmental Monitoring: Utilized for the analysis of organic and inorganic substances in environmental samples, contributing to water quality, atmospheric, and soil pollution monitoring.
III. Advantages:
Efficient Separation: Microfluidic electrophoresis chips achieve highly efficient separation of biomolecules through microchannels and electric fields, enhancing resolution.
High Throughput: Enables parallel analysis of multiple samples, increasing analytical throughput suitable for high-throughput biological research and diagnostics.
Minimal Reagent Usage: Due to the small chip size, the required amount of reagents is significantly reduced, contributing to cost reduction and waste reduction.
Real-time Monitoring: Integration of real-time detection systems allows users to monitor and record the separation of biomolecules in real-time.
Automation: Compatible with automation systems, enhancing experiment standardization and reducing human operational errors.
IV. Challenges:
Sample Preprocessing: The preprocessing of complex samples remains a challenge, requiring effective methods for sample preparation to reduce interference substances.
Sensitivity: Improvements are still needed for high sensitivity to low-concentration biomolecules to meet the requirements of specific applications.
Cost: The manufacturing and usage costs of such chips remain a concern, necessitating the exploration of effective avenues for cost reduction.
Diversity Integration: Further enhancements are required for the multifunctionality and diverse integration of electrophoresis chips to meet the demands of various applications.
V. Future Prospects:
As an innovative technology in the field of bioanalysis, electrophoretic microarrays are expected to play a more important role in the fields of medicine, life science research and environmental monitoring.
Future directions include increasing sensitivity, reducing costs, expanding application areas, and further integrating automation technologies to meet the growing demand for bioanalysis.
The continuous innovation of this technology will promote the development of biomedical research and application fields, providing more possibilities for precision medicine and personalized treatment.
Dxfluidics Products
| Product Code | Outline （mm） | Channel at the electrode | Electrode material | Electrode thickness （nm） | Chip material | Price （CNY） | |
| Height （um） | Width （mm） | ||||||
| E0001 | 50*30 | 100 | 1 | Cr+Au | 5+100 | PDMS+Glass | 1300 |
| E0002 | 21*10 | 100 | 0.8 | Cr+Au | 5+100 | PDMS+Glass | 1000 |
| E0003 | 84*40 | 100 | 0.57 | Cr+Au | 5+100 | PDMS+Glass | 1300 |
| E0004 | 45*22.5 | 100 | 0.75 | Cr+Au | 5+100 | PDMS+Glass | 1000 |
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