The continuous advancement of microfluidic technology has driven the development of the biochip field, in which DLD (Determination of Leukocyte Deformability) sorting chip, as an innovative technology, brings new possibilities in the field of cell sorting.
In this paper, we will introduce the principle, advantages, application areas and future development trend of DLD sorting chip in detail.
I. Principles of DLD Cell Sorting Chip
The DLD sorting chip employs the unique DLD technology, Displacement Directed Sorting, which is based on the motion behavior of tiny particles in a microfluidic channel.
The microchannel surface of the DLD sorting chip is designed with a series of micron-sized obstacles that can cause particles to be deflected in the flow of tiny liquids, thus enabling the sorting of particles.
As cells pass through the microchannel, differences in their morphology and flexibility will result in different offsets in the DLD structure, enabling precise sorting of cells.
II. Advantages of DLD Cell Sorter:
- Efficient Sorting: The DLD cell sorting chip, with its rational design of micrometer-scale obstacles, efficiently sorts cells, allowing for the accurate capture and positioning of individual cells.
- Label-Free Operation: In contrast to some traditional cell sorting methods, the DLD cell sorting chip operates without the need for fluorescent or chemical labeling, avoiding sample interference and simplifying experimental procedures.
- Multi-Channel Design: DLD cell sorter typically incorporate a multi-channel design, enabling the simultaneous processing of multiple samples, thereby enhancing sorting throughput suitable for high-throughput experimental requirements.
- Broad Applicability: Due to its dependence on cell morphology and flexibility, the DLD cell sorting chip is applicable to various cell types, including red blood cells, white blood cells, showcasing its wide-ranging versatility.
III. Application Domains of DLD Cell Sorting Chip:
- Cancer Research: The DLD cell sorter holds significant potential in sorting cancer cells, leveraging differences in cell morphology and flexibility for efficient sorting, thereby providing a crucial tool for cancer research.
- Biomedical Diagnostics: In medical diagnostics, the DLD cell sorting chip can be utilized for the separation and capture of specific cell types, facilitating rapid and accurate cell analysis to support disease diagnostics.
- Drug Screening: The DLD cell sorter is applicable to drug screening experiments, enabling the sorting of different cell types to assess the impact of drugs on cells, providing a robust tool for drug development.
- Genomic Research: In genomic research, the DLD cell sorting chip can be employed to isolate different cell types, assisting researchers in more precisely analyzing gene expression and variations within specific cell subpopulations.
IV. Future Trends of DLD Cell Sorting Chip:
- Multifunctional Integration: Future DLD cell sorting chips may emphasize multifunctional integration, including combining with other microfluidic technologies to achieve more complex cell operations and analyses.
- High Sensitivity Detection: The direction for the future development of DLD cell sorting chips may involve high-sensitivity detection for individual cells, further enhancing sorting accuracy and precision.
- Automation and Intelligence: DLD cell sorter may evolve towards automation and intelligence, integrating advanced control systems and artificial intelligence technologies for more convenient and efficient cell sorting operations.
- Clinical Application Expansion: With ongoing technological advancements and maturation, DLD cell sorting chips are expected to find more widespread applications in clinical medicine, providing additional choices for personalized healthcare and disease diagnostics.
Conclusion
The DLD cell sorter, as an innovative application of microfluidic technology, demonstrates significant potential in the field of cell sorting. Its efficiency, label-free operation, and wide applicability make it suitable for various domains, including cancer research, biomedical diagnostics, drug screening, and genomic research. As technology continues to advance and application domains expand, the DLD cell sorting chip is poised to become a crucial tool in the field of cell sorting, bringing forth innovation and breakthroughs in life science research and medical applications.
Dxfluidics Products
| Product Code | Outline （mm） | microcolumn （um） | Offset angle （um） | Column space （um） | Sorting channel length （mm） | Channel height （um） | Material | Price (CNY) | |
| Shape | Side length/Diameter | ||||||||
| 800001 | 75*25 | triangle | 60 | 2 | 85 | 35.5 | 50 | PDMS+glass | 500 |
| 800002 | 75*25 | triangle | 20 | 2 | 40 | 55 | 50 | PDMS+glass | 600 |
| 800002-1 | 75*25 | circle | 30 | 2 | 40 | 55 | 50 | ||
| 800002-2 | 75*25 | triangle | 20 | 2 | 40 | 55 | 50 | ||
| 800003 | 75*25 | triangle | 30 | 2 | 65 | 28 | 50 | PDMS+glass | 500 |
| 800004 | 75*25 | circle | 40 | 9 | 80 | 4mm*3 | 50 | PDMS+glass | 500 |
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