A 3D cell culture chip is a biotechnology tool used to simulate and study three-dimensional cell growth environments in the laboratory. Traditional cell culture is usually performed in a 2D petri dish, but this method cannot accurately simulate the 3D growth of cells in the human body.
The advent of 3D cell culture microarrays has changed this, allowing researchers to more realistically simulate and study cell growth, interactions and responses in a three-dimensional environment.
3D cell culture microarrays are an advanced biotechnology platform that provides a tool for cellular research that highly mimics the environment of human tissue. By building three-dimensional structures within a tiny scale, such chips more closely resemble physiological environments, prompting cells to grow and interact more naturally.
Compared with traditional 2D culture, 3D cell culture chips can more accurately mimic the behavior and response of cells in an organism, providing a more reliable experimental platform for drug screening, disease research and tissue engineering.
Its microstructural design and highly controllable nature enable researchers to gain insight into the biological behavior of cells, providing innovative solutions for cutting-edge research and new drug development in the life sciences.
Microfluidic cell culture chip product features
1）Diverse gel filling
Gel channels can be filled with collagen, fibronectin, and other hydrogels, or Matrigel™ and other extracellular matrix (ECM).
2）Efficient gas exchange
Made of PDMS material, it enables highly efficient gas exchange, suitable for cell culture.
3）Controllable fluid and chemical concentration gradients
Hydrogels permeate the entire microfluidic cell culture chip, allowing control and adjustment of fluid and chemical concentration gradients.
4）Co-culture model
Different types of cells for microfluidic co-culture can be cultivated in the same channel or separated into different channels.
Application Areas：
Vascular Regeneration: By highly simulating the in vivo environment, it provides a unique experimental platform for in-depth exploration of vascular formation and its regulatory mechanisms. This technology, utilizing microfluidic systems and microstructure design, can simulate complex cell interactions and physiological environments. Researchers can comprehensively and finely study the growth, differentiation, and reconstruction processes of vascular networks. This supports the development of cardiovascular disease research, drug screening, and regenerative medicine in the field of vascular regeneration, fostering a deeper understanding of vascular biology.
Cancer Cell Metastasis: The occurrence of cancer cell metastasis is a multi-stage event, including cancer cell dissemination/invasion, intravasation, and extravasation. Each stage can be individually modeled in 3D cell culture chips.
Cell Invasion and Migration: 3D cell culture chips are suitable for tracking cell migration by creating a 3D network or measuring migration endpoints.
Dxfluidics Products
| Product Code | large channel dimensions | Microcolumn dimensions | Pore Diameter （mm） | Thickness （mm） | Chip material | Price （CNY） | ||||
| outer （mm） | inner （mm） | Space （mm） | Length （mm） | Height （mm） | Space （mm） | |||||
| 400001 | 0.5 | 1 | 0.15 | 0.32 | 0.25 | 0.1 | 1&4 | 4+1+1 | PDMS+Glass | 500 |
| 400002 | 0.5 | 1 | 0.15 | 0.32 | 0.25 | 0.1 | 1&4 | 4+1 | PDMS+Glass | 300 |
| Product Code | Outline （mm） | Channel | Side groove | Middle groove | Material | Price （CNY） | ||||
| Height （mm） | Length （mm） | Width （mm） | Depth （mm） | Diameter （mm） | L*W （mm） | Height （mm） | ||||
| 400003 | 75*25 | 0.38 | 50 | 1.48 | 5mm | 4mm | / | / | PDMS+Glass | 400 |
| 400004 | 75*25 | 0.38 | 50 | 1.48 | 5mm | 4mm | 3*3 | 2 | PDMS+Glass | 400 |
| Product Code | large channel dimensions | Microcolumn dimensions | Pore Diameter （mm） | Thickness （mm） | Chip material | Price （CNY） | ||||
| outer （mm） | inner （mm） | Space （mm） | large holes （mm） | Height （mm） | small holes （mm） | |||||
| 400005 | 1 | 1 | 0.32 | 0.78 | 0.5 | 0.32 | 1.6 | 4+1 | PDMS+Glass | 300 |
| 400006 | 1 | 1 | 0.32 | 0.7 | 0.5 | 0.3 | 1.6 | 4+1 | PDMS+Glass | 300 |
| 400007 | 0.5 | 0.5 | 0.68 | 0.87 | 0.5 | 0.3 | 1.2&4 | 4+1 | PDMS+Glass | 300 |
| 400008 | 1 | 0.65 | 0.12&0.23 | 0.25 | 0.25 | 0.16 | 1.2&4 | 4+1 | PDMS+Glass | 300 |
| 400009 | 1 | 0.9 | 0.2 | 0.33 | 0.25 | 0.1 | 1.2&4 | 4+1 | PDMS+Glass | 300 |
| 400010 | 0.95 | 0.5 | 0.32&0.2 | 0.24 | 0.25 | 0.08 | 1.2&2 | 4+1 | PDMS+Glass | 300 |
| 400011 | 0.3 | 0.5 | 0.57/0.75 | 1 | 0.25 | 0.3 | 1&2 | 4+1 | PDMS+Glass | 300 |
Cell culture insert refers to a permeable membrane or support system placed in a culture dish or well. It is commonly used in cell culture experiments to create a barrier or compartment for studying the interaction between cells or substances on either side of the membrane. The insert allows for the exchange of soluble factors while physically separating different cell populations or environments. This product is made of PDMS material, and each chamber at the bottom is connected by microchannels.
| Product Code | Chamber | Channel | Chamber pore size （um） | Chip material | Price （CNY） | ||
| Diameter （mm） | Height （mm） | Height （mm） | Width （mm） | ||||
| 400012 | 25 | 20 | 0.25 | 0.1 | 0.1，0.4，1， 3，5，8，12 | PDMS+Glass | 1500 |
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