Cell migration refers to the movement of cells in response to migration signals or the detection of concentration gradients of certain substances. During the movement, cells repeatedly extend protrusions or pseudopodia forward, followed by the retraction of the rear cell body in a cyclical process. The material basis for this process includes the cell cytoskeleton, associated proteins, and the cell matrix. Additionally, various substances intricately regulate this process.
Cell migration chip is a type of biochip based on microfluidic technology, used to simulate the migration process of cells under different physiological and pathological conditions in the body. Cell migration is a crucial step in many biological processes, including embryonic development, tissue repair, and immune response.
The cell migration chip typically consists of a microchip, pumps, and a fluid control system. Different cell migration models, such as models for cell adhesion and migration, cell chemotaxis, and cell-cell interaction, can be prepared on the surface of the chip using biological and chemical methods. Cells in the chip can be processed, cultured, and observed through a microfluidic system.
With the cell migration chip, researchers can simulate the cell migration process in vivo, explore the mechanisms and influencing factors of cell migration, study diseases and drugs related to cell migration, and develop new drug screening methods. Cell migration chips have been widely applied in biomedical research, life sciences, and drug development.
Experimental Method for Cell Culture Chip
1、Prepare the microfluidic chip: Coat the chip surface with collagen or other cell adhesion agents and design corresponding channel structures as needed.
2、Cell culture: Add culture medium and cell suspension to the chip, allowing cells to settle on the chip surface. After cell attachment, add appropriate culture medium to maintain cell growth.
3、Experimental operation: Connect the Cell Culture Chip to a pressure pump or other external device to control the flow speed and direction of the fluid in the chip. Then, add cell inducers or other chemicals to observe the cell migration process.
4、Observation and recording: Use a microscope to observe cell movement and behavior and record data through relevant software.
5、Data analysis: Analyze and interpret the observed data based on the experimental purpose and perform statistical analysis if necessary.
It is essential to control cell density and flow velocity in the channel during microfluidic cell migration chip experiments to ensure the accuracy and reliability of experimental results. Additionally, researchers should adhere to relevant experimental specifications and safety operating requirements.
Latest Research Progress and Development Directions:
细胞迁移芯片/类器官芯片是一种应用微流控技术和微纳米制造技术，用于模拟细胞迁移过程的微型实验平台。它已经被广泛应用于肿瘤转移、器官发育、血管生成等领域的研究中，并取得了显著的研究进展。
Below are the latest research advances and developments in cell migration microarrays:
1、Multifunctionality: Current cell migration chips/organ-on-chips are mainly used to observe the cell migration process. Future research will focus on the multifunctionality of the chip, including incorporating other functional modules such as cell culture, cell differentiation, and cell signal transduction, to better simulate the complex environment in the body.
2、Precision and Reproducibility: The rapid development of microfluidic technology has significantly improved the precision and reproducibility of cell migration chips. Future research will further enhance the precision of Cell Culture Chip fabrication and the stability of flow control to better meet the needs of scientific research and practical applications.
3、Artificial Intelligence and Automation: In large-scale high-throughput research, artificial intelligence and automation will play an increasingly important role. Future research will develop cell migration chips based on artificial intelligence and automation to achieve efficient experimental operations and data analysis.
4、Applications: Cell migration chips have been widely applied in research on cancer metastasis, tumor microenvironments, angiogenesis, etc. Future research will further expand the application areas, including tissue engineering, regenerative medicine, toxicology, etc.
In summary, cell migration chips/organ-on-chips will continue to play a crucial role in biology, medicine, and other fields. Future research will further improve their precision and multifunctionality, and develop new technologies and applications based on artificial intelligence and automation.
Dxfluidics Customized Products
| Product Code | large channel dimensions | bridge dimensions | punching dimensions （mm） | chip thickness （mm） | Chip material | price（CNY) | ||||
| outer （mm） | inner （mm） | Space （mm） | Width （um） | Height （um） | Space （um） | |||||
| 300001 | 1.5 | / | 0.4 | 4 | 5 | 20 | 8 | 4.5 | PDMS | 500 |
| 300002 | 0.2 | 0.2 | 0.2 | 5 | 5 | 20 | 1 | 4.5 | PDMS | 500 |
| 300003 | 1 | 1 | 0.2 | 10 | 5 | 15 | 3.5 | 4.5 | PDMS | 500 |
| 300004 | 0.2 | 0.2 | 0.1 | 3 | 5 | 20 | 2.6 | 4.5 | PDMS | 500 |
| 300005 | 1 | 1 | 0.5 | 10 | 5 | 15 | 2 | 4.5 | PDMS | 500 |
| 300006 | 1 | 2 | 0.1 | 4 | 5 | 36 | 1 | 4.5 | PDMS | 500 |
| 300007 | 0.1 | 0.4 | 0.2 | 10 | 5 | 10 | 1.6 | 4.5 | PDMS | 500 |
| 300008 | 1 | 1 | 0.5 | 10 | 5 | 60 | 5 | 4.5 | PDMS | 500 |
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DXFLUIDICS
Dxfluidics is a specialized enterprise dedicated to customizing various microfluidic organ chips. With a highly skilled and experienced processing team, we offer one-stop organ chip processing services for our clients. The company is committed to providing high-quality, high-performance biochip products for the fields of biomedicine, biomedicine, bio-detection, cell culture, and more.
Let the flower of life bloom more beautifully, Dxfluidics microfluidic organ chips make miniature life experiments more precise!
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