The Sperm Screening Chip is an advanced technological tool designed for fertility treatments. Its core benefits include efficient sorting of desirable spermatozoa, eliminating the need for tedious sample preparation, and a standardized, streamlined procedure.
This chip innovatively combines optimized channel size and incubation time to maximize sorting efficiency. With this technology, high-quality spermatozoa with high motility, normal morphology, low ROS and low DNA breaks can be quickly and precisely selected.
The Sperm Screening Chip not only significantly reduces sample preparation time, but also mitigates the effects of traditional centrifugation on semen quality, providing embryologists with an efficient and easy method to help them select the highest quality sperm, thereby enhancing the success of fertility treatments.
Microfluidic organs-on-chips are miniature chip systems that simulate biological organs, allowing the emulation of complex biological processes at a microscopic scale, including cell differentiation, tissue development, and disease progression. These chips find extensive applications in biomedical research, drug screening, and toxicity assessment.
The sperm sorting chip is a microfluidic technology-based chip system enabling efficient sorting and selection of sperm. This technology holds great promise in the field of Assisted Reproductive Technology (ART) and can be utilized for sperm quality assessment, diagnosis, and treatment of male infertility.
Typically composed of microchannels, filtering layers, and sperm capture layers, the sperm sorting chip controls the flow and distribution of sperm through microchannels, precisely sieves and selects sperm based on specific characteristics (such as vitality, morphology, and size), and efficiently captures target sperm while separating them from others.
Advantages of microfluidic organ sperm sorting chips include high efficiency, accuracy, good repeatability, and time and cost savings. This technology can be combined with other biotechnologies like electron microscopy, fluorescence microscopy, and single-cell sequencing to further improve the precision and efficiency of sperm sorting.
Latest Research Advances and Development Directions in Microfluidic Sperm Sorting Chips
Sperm sorting chips are continuously evolving and improving, with promising applications in various fields such as biomedical research, animal reproduction, and poultry breeding. Here are the latest research advances and development directions:
1.High Throughput Sorting Chips: Researchers are exploring strategies for achieving more efficient sorting and selection. One approach is the use of multi-channel microfluidic chips, capable of simultaneously processing multiple samples, greatly enhancing sorting speed and sample throughput.
2.Biomaterial Modification: Modifying chip surfaces with biomaterials can improve sperm adhesion and release, enhancing sorting efficiency and accuracy. For example, some researchers use polylactic acid-polyethylene glycol copolymers as chip materials to significantly reduce nonspecific adsorption of sperm to the chip surface, improving sorting results.
3.High Sensitivity Detection Techniques: Developing higher sensitivity detection techniques is crucial for extremely low sperm concentration samples. For instance, some researchers use fluorescence-labeled antibodies or molecular probes in conjunction with microfluidic chip technology to detect and locate individual sperm, significantly improving detection sensitivity and resolution.
4.Expanded Applications: Microfluidic sperm sorting chips are not limited to human and animal assisted reproduction; they can also be applied to poultry breeding and other fields. For example, researchers apply microfluidic chip technology to assess and select the quality of poultry semen, effectively improving poultry breeding efficiency and quality.
In summary, sperm sorting chip technology is continually evolving and holds great potential for widespread applications in biomedical research, animal reproduction, and other fields in the future.
Research Papers on Microfluidic Sperm Cell Culture Chips
1. Title: "Microfluidic sperm sorting device with PDMS and SU-8 microstructures" Authors: Liu, Y. J. et al.
Summary: This paper describes a microfluidic sperm sorting device that utilizes PDMS and SU-8 microstructures. The device achieves efficient sperm sorting through different physical isolations and screenings, demonstrating good stability and repeatability with high-efficiency large-scale sperm sorting capabilities.
2.Title: "Microfluidic chip for sperm selection based on hyaluronic acid-induced motility" Authors: Li, W. J. et al.
Summary: This paper introduces a cell culture chip based on hyaluronic acid-induced sperm motility, efficiently selecting sperm with good motility. The chip is noted for its more efficient selection of high-quality sperm compared to traditional manual methods, offering better protection of sperm integrity and vitality.
3.Title: "A microfluidic chip for spermatozoa separation" Authors: Iverson, W. et al.
Summary: This paper describes a microfluidic cell culture chip utilizing differences in hydrophobicity between liquid and gas phases to achieve sperm separation. The chip efficiently separates sperm with different characteristics, including varying vitality and morphology, holding broad applications in infertility treatment and artificial insemination.
4.Title: "A microfluidic chip for the sorting of motile spermatozoa" Authors: Zhu, Y. et al.
Summary: This paper introduces a microfluidic sperm sorting chip utilizing electric field effects to select sperm with good motility. The chip efficiently sorts high-quality sperm without compromising integrity and vitality, offering applications in infertility treatment and artificial insemination.
5.Title: "Microfluidic Chip for Continuous Sperm Sorting and Analysis",Authors: Huang, Y. et al.
Summary: This paper presents a microfluidic chip for continuous sperm sorting and analysis, including both sorting and analysis modules. The chip efficiently separates sperm with different characteristics and enables real-time analysis and monitoring, holding broad applications in infertility treatment and artificial insemination.
Dxfluidics Customized Products
| Product Code | Dimensions (mm) | Top chamber | Bottom champer | Pore membrane | Chip material | Price （CNY） | ||||
| Height （mm） | Diameter （mm） | Height （mm） | Diameter （mm） | Thickness （um） | Hole diameter （um） | Material | ||||
| 500001 | 60*30 | 8.5 | 20 | 2.4 | 20 | 10 | 3/5 | PET/Nylon/PTFE | PDMS+PDMS+glass | 700 |
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DXFLUIDICS
Dxfluidics is a specialized enterprise dedicated to customizing various microfluidic organ chips. With a highly skilled and experienced processing team, we offer one-stop organ chip processing services for our clients. The company is committed to providing high-quality, high-performance biochip products for the fields of biomedicine, biomedicine, bio-detection, cell culture, and more.
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