In today's biomedical research field, organ chip/cell culture chip/organoid chip technology is pushing the boundaries of science at an astonishing speed. In order to realize more realistic and efficient biological experiments, organ chip/cell culture chip/organoid chip processing equipment has become an indispensable key element.
We have launched a series of advanced equipments including desktop lithography, homogenizer, developer, PDMS paster, PDMS defoamer, oven, PDMS punch, PDMS dicer, and plasma bonding machine, which synergistically help to prepare high-quality organoids/cell culture microarrays/organoids and open up the journey of advanced bio-research to advance drug discovery, disease research and personalized medicine.
The main material of organochip/cell culture chip/organoid chip is fully called polydimethylsiloxane, which is a transparent, elastic and biocompatible silicone-based elastomer, usually processed with the help of soft lithography. The preparation process is divided into two parts, one is the preparation of the mold and the other the preparation of the chip.
PDMS Organ-on-Chip Mold Preparation
The material of organoids/cell culture chips/organoid chips is PDMS, and the preparation of PDMS chips is done by molding method, and the selection of suitable molds is crucial for the preparation of microstructured chips.
In the process of preparing PDMS chips, commonly used molds include SU-8 molds, pure silicon molds, and acrylic molds. These molds play a key role in microstructure preparation, and their selection and design have an important impact on the performance and application of the final chip.
SU8Mold Preparation
SU-8 is a high-resolution negative photoresist with excellent mechanical, dielectric, chemical resistance, and thermal properties, along with outstanding biocompatibility. Molds prepared with SU-8 possess the following advantages:
1 High resolution and precision: SU-8 is a high-resolution photoresist, allowing the fabrication of complex and intricate microchannel geometries through photolithography. This results in well-defined microfluidic structures.
2 Tough and durable: SU-8 molds exhibit toughness and durability, enduring repeated use, cleaning, and handling without significant degradation. They are suitable for multiple PDMS chip castings.
SU-8 molds, utilizing photolithography processes, can manufacture line widths greater than 2 micrometers on SU-8 templates and achieve aspect ratios in structures ranging from 1:1 to 2:1. Additionally, with the aid of multilayer photolithography techniques, it is possible to create microchannel structures with different heights on SU-8 molds.
The SU8 mold processing platform includes: Desktop Photolithography Machine, Spin Coater, Developer. For equipment details, please refer to:SU-8 Mold Processing Platform.
Equipment for PDMS Chip Preparation
The PDMS chip preparation equipment includes: PDMS Pouring Machine, PDMS Debubbler, Oven, PDMS Puncher, PDMS Cutter, and PDMS Plasma Bonder. For details, please refer to:PDMS Chip Processing Platform.
organ-on-a-chip
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