微流控塑料芯片是一种利用聚合物材料制成的微小实验室设备,具有微通道和微腔室,用于控制和分析微流体。相比于传统的玻璃芯片,塑料芯片具有成本低、制备灵活、质轻易加工等优势。
这种芯片被广泛应用于生物医学、化学分析、环境监测等领域。其微小尺寸和高度集成性使其能够有效地进行微反应、细胞培养、药物筛选等实验,为实验室研究提供了便捷的工具。
微流控塑料芯片在推动微流体技术的发展,以及促进实验室实验的自动化和高通量化方面发挥着关键作用。
PMMA芯片材质PMMA是一种廉价的易于制造的聚合物,它是普通塑料材料中最不疏水的聚合物,并且易于改性。
由于其低价格,刚性机械性能,优异的光学透明性和与电泳的兼容性,它对于一次性微流控塑料芯片特别有用。它也是制备可重复使用的微流控塑料芯片的理想材料。
PMMA chip dvantages: Low cost, hydrophilic among common plastics, rigid mechanical properties, excellent optical transparency, compatibility with electrophoresis, easy to manufacture and modify, reusable.
PMMA chip disadvantages: Expensive equipment required for complex chip fabrication (injection molding, hot embossing).
PMMA chip Common Applications: Eco-friendly microchips (reusable), hybrid analysis chips, DNA sequencers, electrophoresis chips.
PMMA chip Forming Methods: CO2-laser micromachining, injection molding, hot embossing, compression molding, and extrusion.
Glass Transition Temperature: 85-165°C (varies with grade).
COC芯片具有良好的耐水解性,耐酸性试剂,碱性试剂以及大多数有机极性溶剂,如丙酮,甲醇和异丙醇。COC芯片材料对波长超过250nm的光具有高透明度并且具有低自发荧光。
由于COC芯片表面的疏水性,使得用其制造的芯片暴露于生物组织或液体时易于发生自发的非特异性蛋白质吸附和细胞粘附,这使得其不能成为用于涉及药物的研究的最佳选择。
Advantages of COC Chips:Excellent resistance to hydrolysis, resistance to acidic and alkaline substances, and most organic polar solvents. High transparency to light with wavelengths above 250nm, low autofluorescence, low birefringence, high Abbe number, and high heat resistance.Low water absorption and high dimensional stability.
Disadvantages of COC Chips:Expensive equipment is required for injection molding and hydrophobic surface treatment to mitigate analyte adsorption and reduce cell adhesion.
OC Chip Forming Methods:Single and twin-screw extrusion, injection molding, injection stretch blow molding (ISBM), compression molding, extrusion coating, biaxial orientation, thermoforming, and others.
Glass Transition Temperature: 70-177°C (depends on polymer content).
Polycarbonate (PC) is the preferred durable material for a range of microfluidic applications in biomedical research and bioanalysis. It is commonly used in DNA thermal cycling applications, such as Polymerase Chain Reaction (PCR), due to its visible light transparency and exceptionally high glass transition temperature (145°C).
Advantages of PC Chips:Durable material with high transparency in the visible light region.Extremely high glass transition temperature (~145°C), providing resilience.Low cost, high impact resistance, low moisture absorption, and good processing performance.
Disadvantages of PC Chips:Limited resistance to certain organic solvents, UV light absorption. Limited bonding quality and strength (restricted to heat bonding).Changes in channel geometry due to bonding temperature.
Common Applications:DNA thermal cycling, manufacturing of multilayer devices, enzyme-catalyzed amplification, nucleic acid separation, amplification product labeling, pathogen detection, and microfluidic injection ampereometric determination of glucose.
Glass Transition Temperature:145-155°C.
聚苯乙烯(PS)是光学透明的,惰性的,生物相容的,刚性的,便宜的并且易于商业化的热塑性材料,这使其成为细胞培养中最常用的材料。
其表面易于进行处理(可采用各种物理和化学方法,包括辐照,电晕放电或气体等离子体),使其疏水表面更具亲水性。
然而,需使用昂贵的设备来加工制造这种聚合物的复杂芯片(注塑,热压)是在芯片原型研发中的主要缺点,因为PS更适合于大规模制造工艺。
Advantages of PS Chips:Optical transparency, biocompatibility, inertness.Easily treatable surface adaptable to mass manufacturing processes. High commercial availability, low cost, and quick bonding.
Disadvantages of PS Chips:Expensive equipment required for complex chip manufacturing (injection molding, hot pressing).Challenges in heat bonding during the manufacturing of chips with this polymer, especially when the width-to-height ratio is too high, leading to more channel collapses.
Common Applications:Cell culture research.
Potential Applications: Cell culture on microfluidic chips (organ-on-a-chip), utilizing plasma treatment or masking layers. Pre-coating microchannels with extracellular matrix proteins before cell seeding to facilitate cell adhesion and growth while preventing bubble formation.
Forming Methods: Injection molding, hot embossing.
Glass Transition Temperature: 92-107°C.
The primary processing methods include machining, hot embossing, and injection molding.
In the prototyping stage, machining is mainly used, while injection molding is favored for mass production. A variety of processing equipment is available to meet different customer needs at different stages.
Microfluidic plastic chip bonding methods mainly include hot pressing, ultrasonic bonding, and laser bonding. Currently, hot bonding is the predominant method.
DingXu (Suzhou) Microfluidics Technology Co., Ltd. is a high-tech enterprise dedicated to the field of microfluidics. We are committed to providing customers with comprehensive microfluidic solutions, including customized microfluidic chip development, surface modification, microfluidic chip processing equipment, and microfluidic instruments. Our team boasts extensive experience and technical expertise, continuously combining professional knowledge with innovative thinking to deliver high-quality solutions. We consistently prioritize customer-centric values, embrace self-challenges, and pursue excellence. Through professionalism, innovation, and collaboration, we aim to create greater value for our customers and contribute to a brighter future in the field of microfluidics.
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