微流控乳腺芯片是一种用于模拟乳腺组织的微型生物反应器,它可以在体外重建乳腺组织的结构和功能,用于研究乳腺癌发生、发展的机制以及筛选药物。
该芯片采用微流控技术,在微米尺度内控制流体的流动,使细胞、生长因子和药物等微量物质能够在芯片内进行复杂的反应过程。
微流控乳腺芯片通常由微型生物反应器、微型流控系统、检测系统等组成,可以模拟乳腺组织的微环境,包括细胞-细胞相互作用、细胞-基质相互作用、细胞与微环境因素(如药物、激素等)的相互作用等。
通过这种模拟,研究者可以更加真实地观察乳腺癌的发生、发展机制,并且可以用于乳腺癌的个性化治疗方案的筛选。
微流控乳腺芯片的研究还处于发展初期,但已经取得了一些重要进展,例如可以重建乳腺小叶的结构,研究乳腺癌细胞与微环境相互作用的机制等。
未来,微流控乳腺芯片还将继续发展,例如可以与其他微流控芯片结合,建立更加复杂的肿瘤器官芯片,进一步深入研究肿瘤发生的机制。
The Microfluidic Mammary Chip is an in vitro bionic breast tissue model that can be used to explore mammary gland development, cancer occurrence and treatment by simulating the in vivo environment. The experimental methodology of the Mammary Chip is as follows:
The experimental methodology of mammary microarrays can be flexibly adapted to the specific research question, e.g., different types of cells can be used, different biologically active substances can be added, etc.
Microfluidic breast microarrays are an important bionic model for studying the mechanisms of breast biology and carcinogenesis, as well as for drug screening and therapeutic studies. In recent years, the research progress of microfluidic breast microarrays is as follows:
未来,微流控乳腺芯片的研究将更加注重乳腺癌的精准医疗研究,包括肿瘤微环境、肿瘤干细胞、肿瘤免疫治疗等方面,为乳腺癌治疗提供更加有效的方法和策略。
同时,与其他微流控器官芯片的联合研究将成为未来的热点方向。
This review article summarizes the current research progress in microfluidic breast microarrays and introduces different tissue microarray platforms and their applications, including fat, blood vessels, and extracellular matrix. In addition, the article discusses the advantages and disadvantages of these platforms for breast cancer simulation, as well as future directions.
这篇文章报道了一种新的微流控乳腺芯片平台,可以高通量地定量分析三维多细胞模型中的药物效应。该平台由数百个微小的凹槽和通道组成,用于固定和培养多种细胞类型。
通过这种平台,可以在数小时内同时测试多个药物和剂量,并进行快速分析。作者将该平台应用于药物筛选和细胞相互作用的研究中,为未来开发更有效的抗乳腺癌药物提供了新的思路。
These studies indicate that microfluidics has a broad application in the field of breast cancer research and is expected to advance our understanding of the disease and accelerate the development and translation of new drugs.
Cell migration microarrays to study cell-to-cell interactions and the effects of perfusion versus diffusion-based, real-time analysis of experiments with all cell populations, Cell migration microarrays are designed to mimic the formation and transport of tight and gap junctions (e.g., the blood-brain barrier and other endothelial/tissue interfaces), and are available with a wide range of choices in channel sizes, tissue compartment sizes, and scaffolds, as well as barrier designs.
Slit Barrier: This device utilizes slits spaced at regular intervals to form a barrier area between the outer and inner chambers.
Available standard design parameters include:
Dxfluidics is a specialized enterprise dedicated to customizing various microfluidic organ chips. With a highly skilled and experienced processing team, we offer one-stop organ chip processing services for our clients. The company is committed to providing high-quality, high-performance biochip products for the fields of biomedicine, biomedicine, bio-detection, cell culture, and more.
Let the flower of life bloom more beautifully, Dxfluidics microfluidic organ chips make miniature life experiments more precise!
DingXu (Suzhou) Microfluidics Technology Co., Ltd. is a high-tech enterprise dedicated to the field of microfluidics. We are committed to providing customers with comprehensive microfluidic solutions, including customized microfluidic chip development, surface modification, microfluidic chip processing equipment, and microfluidic instruments. Our team boasts extensive experience and technical expertise, continuously combining professional knowledge with innovative thinking to deliver high-quality solutions. We consistently prioritize customer-centric values, embrace self-challenges, and pursue excellence. Through professionalism, innovation, and collaboration, we aim to create greater value for our customers and contribute to a brighter future in the field of microfluidics.
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