微流控脑器官芯片(Microfluidic Brain-on-a-Chip)是一种基于微流控技术的生物芯片,用于模拟人类大脑的结构和功能。
它由微型流体通道、微加工芯片和人类神经细胞构成,可以在微米尺度上控制流体的流动和混合,模拟人脑内的复杂流动和传质过程。
微流控脑芯片的设计目的是为了替代传统的细胞培养和动物实验模型,以提高神经科学研究和神经药理学领域的效率和准确性。
它可以在微型通道和腔室中培养人类神经细胞,以实现体内的生理环境,如控制神经元类型、密度和分布,模拟突触传递、神经信号传导和神经发育过程,同时还可以模拟神经系统的疾病状态和药物反应。
微流控脑芯片的应用范围非常广泛,包括神经退行性疾病、神经精神疾病、脑外伤、脑肿瘤等。
它不仅可以用于药物筛选和剂量测试,还可以用于神经疾病的病理机制研究和治疗方案的优化,为神经科学领域的研究提供了新的方法和工具。
Microfluidic brain organoids are a novel experimental platform for studying the nervous system. The following is the general experimental method:
It should be noted that microfluidic brain organ-chip experiments require high technical and equipment support, high skill requirements for experimenters, and strict quality control.
Microfluidic brain organoids, as a novel neuroscience experimental platform, have received extensive attention and research in recent years. The following are some of the latest research progresses:
In conclusion, the research on microfluidic brain organoids is making new progress, which is expected to provide a more accurate, efficient and reproducible experimental platform for neuroscience research and drug development.
Below are some literature recommendations on microfluidic brain organoids and their brief overviews:
1. "Human Brain Organoids on a Chip Reveal the Physics of Folding" (Nature Physics, 2021) - This study uses a microfluidic chip to culture human brain organoid structures and reveals the mechanism of organ fold formation by investigating the physics of organ folding. -like structures using a microfluidic chip and reveals the mechanism of cortical fold formation by characterizing the physics of organ folding.
2. "Microfluidic Brain-on-a-Chip for Modeling Cortical Development and Folding" (Science Advances, 2021) - This study used a microfluidic chip to model the development and folding of the cerebral cortex and regulate the folding morphology of the cerebral cortex by varying the ratio of neurons to astrocytes in the chip.
3. "Microfluidic Neurovascular Unit Model to Recapitulate Cerebral Ischemia-Reperfusion" (ACS Biomaterials Science & Engineering, 2021) - This study used a microfluidic chip to create a neurovascular unit model to simulate the process of cerebral ischemia-reperfusion, providing a new experimental platform for the study of stroke and other neurovascular diseases.
4. "Microfluidic organ-on-a-chip models of human brain disorders" (Nature Reviews Neuroscience, 2020) - The review article provides an overview of recent research on the use of microfluidic chips to simulate human brain organs, and their application to the study of neurological disorders.
These studies demonstrate the potential of microfluidic brain organoids as a novel neuroscience experimental platform and provide new ideas and methods for neuroscience research and disease treatment.
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