Introduction
心脏疾病一直是全球范围内的主要健康问题,而药物的研发和筛选对于治疗这些疾病至关重要。近年来,一种名为工程心脏组织芯片(器官芯片的一种,属于微流控芯片范畴)的创新技术引起了广泛关注。
该技术利用工程心脏组织(EHT)创建了一种独特的药物筛选平台,通过模拟真实心脏组织的三维结构和机械响应性,为研究人员提供了更真实、可控的实验环境。
本文将深入探讨工程心脏组织芯片的关键特点、优势以及其在心脏组织发展和药物研发领域的潜在应用。
1. Background
心脏疾病是全球范围内的主要死因之一,对于有效治疗和预防这些疾病的关键在于深入了解心脏组织的生理和病理过程。
传统的细胞培养和动物试验虽然有助于研究心脏细胞的一些特性,但由于其局限性,仍然无法完全模拟复杂的心脏组织环境。因此,迫切需要一种新的技术来提高药物筛选的效率和准确性。
2. Key Features of Engineered Heart Tissue Chips
2.1 Multi-species Cardiac Cell Embedding
The uniqueness of Engineered Heart Tissue Chips lies in their utilization of cardiac cells from different species, including rodents and humans. This feature enhances the chip's biological diversity, allowing for a more authentic simulation of the human physiological environment and providing more reliable data for drug development.
2.2 Three-Dimensional Structure and Mechanical Responsiveness
通过将心脏细胞嵌入含有聚二甲基硅氧烷(PDMS)的纤维蛋白凝胶中,该器官芯片能够产生具有三维结构和机械响应性的EHT。
这种模拟真实心脏组织的能力使得研究人员能够更深入地了解药物对心脏细胞的影响,为精准医学研究奠定基础。
2.3 Efficient Production and Improved Cultivation Environment
该平台具有每周生成数百个EHT的高效生产能力,虽然其生产仍然受心脏细胞可用性的制约。
此外,在改进的培养环境中进行了辅助肌肉收缩的评估,展示了微流控芯片在模拟更真实的生理环境中的改进。这使得工程心脏组织芯片成为高通量药物筛选的有力工具。
2.4 Customized Design
Designed for 24-well plates, the customization enhances the organ chip's ease of use and applicability for standard laboratory operations and high-throughput screening. This tailored design improves the practicality and versatility of the microfluidic chip, making it a preferred platform for researchers.
3. Application Prospects
As an emerging platform for drug screening, Engineered Heart Tissue Chips offer promising avenues for the development of cardiac tissue and preclinical drug research. The simulation of three-dimensional structure and mechanical responsiveness enables researchers to comprehensively assess the effects of drugs on the heart, providing more accurate data for the discovery and development of new drugs.
4. Challenges and Outlook
Despite the immense potential demonstrated by Engineered Heart Tissue Chips in drug screening, challenges persist. One such challenge is the availability of cardiac cells, directly impacting production efficiency. Additionally, further research is required to validate the accuracy and reliability of the chip in simulating a real cardiac environment.
In the future, Engineered Heart Tissue Chips are poised to make significant breakthroughs in cardiac pathophysiology, drug screening, and new drug development. With continuous technological advancements and deepening research, this platform is expected to become an engine driving innovation in the field of cardiac medicine, contributing significantly to the improvement of patients' quality of life.
Conclusion
Engineered Heart Tissue Chips, as an innovative drug screening platform, provide researchers with a more realistic and controllable experimental environment by simulating the three-dimensional structure and mechanical responsiveness of real heart tissue. Key features such as multi-species cardiac cell embedding, efficient production, and improved cultivation environments position these chips as important tools in cardiac disease research and pharmaceutical development. Despite facing some challenges, continuous improvement and expanded applications make Engineered Heart Tissue Chips increasingly vital for future breakthroughs in cardiac medicine.
DXFLUIDICS
Dxfluidics can provide the processing of Engineered Heart Tissue Chips.
Product Code | Number of Slots | Antenna Size | Material | Price(CNY) | ||
Length(mm) | Diameter(mm) | Space(mm) | ||||
100001 | 2 | 10 | 1 | 8.5 | PDMS | 600 |
100002 | 4 | 10 | 1 | 8.5 | PDMS | 1000 |
Product Code | Slot Size | Material | Price(CNY) | |||
Length(mm) | Width (mm) | Height (mm) | ||||
100003 | 2 | 13.5 | 12 | 3 | PTFE | 200 |
100004 | 4 | 13.5 | 12 | 3 | PTFE | 400 |
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