生物芯片表面的亲水改性是通过引入亲水性修饰剂或改变表面化学性质,使表面具有亲水性,从而实现对水或水性液体的吸附和湿润效果。
亲水改性可以促进生物芯片与水性液体的相互作用,有利于分子识别、细胞培养和流体操控等应用。以下是一些常见的生物芯片表面亲水改性方法:
1 亲水分子自组装:利用自组装原理,在生物芯片表面引入具有亲水性的有机分子层。常用的亲水分子包括羟基化合物、聚乙烯醇(PVA)、聚丙烯酸(PAA)等。
这些分子可以在表面形成覆盖层,提高表面的亲水性,使水分子能够吸附并湿润表面。
2 表面活性剂涂覆:通过涂覆表面活性剂,如十二烷基硫酸钠(SDS)、十六烷基三甲基溴化铵(CTAB)等,在生物芯片表面形成亲水层。
表面活性剂的分子结构中含有亲水基团,可以降低表面张力,使表面具有亲水性。
3 等离子体处理:利用等离子体处理技术,对生物芯片表面进行化学修饰,增加亲水性。等离子体处理可以使表面上的官能团发生改变,形成亲水化学基团,如羟基、羧基等。
这些化学基团赋予表面亲水性,并且在处理过程中可以实现较高的加工精度和控制。
4 Oxidation treatment: Oxidation treatment can form an oxide layer on the surface of the biochip and increase the hydroxyl content of the surface, thus improving hydrophilicity. Commonly used oxidation treatment methods include air plasma treatment, oxygen plasma treatment, wet oxidation and so on.
这些方法可以单独应用或结合使用,根据需要和实际应用场景选择适合的亲水改性方法。
亲水改性可以促进生物芯片与水性液体的相互作用,提高分子吸附和细胞附着的效率,对于生物分析、细胞培养和微流控等领域具有重要意义。
Surface hydrophilic treatment effect
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DingXu (Suzhou) Microfluidics Technology Co., Ltd. is a high-tech enterprise dedicated to the field of microfluidics. We are committed to providing customers with comprehensive microfluidic solutions, including customized microfluidic chip development, surface modification, microfluidic chip processing equipment, and microfluidic instruments. Our team boasts extensive experience and technical expertise, continuously combining professional knowledge with innovative thinking to deliver high-quality solutions. We consistently prioritize customer-centric values, embrace self-challenges, and pursue excellence. Through professionalism, innovation, and collaboration, we aim to create greater value for our customers and contribute to a brighter future in the field of microfluidics.
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