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Mother Machine chip

Microfluidic mother machine chip is an advanced biochip technology that integrates microfluidics and cell biology, aiming to simulate and study various stages of mother cells in the cell cycle and related molecular and biological processes. This technology utilizes microstructures such as microchannels, microreactors, and microvalves for highly precise manipulation and observation of mother cells at the microscopic scale. The following is a detailed overview of the mother machine chip, covering its principles, applications, advantages, and potential impact on cell biology and medical research.

Plant microfluidic chips

Plant microfluidic chips are increasingly important tools in the field of plant science, with applications spanning plant growth, plant physiology, and plant stress responses. These chips leverage microfluidic technology to finely control and analyze plants through microchannels and microreactors, providing a novel approach to studying plant growth and development, metabolic processes, and plant responses to environmental changes. The following is an overview of plant microfluidic chips, including their principles, applications, advantages, and potential contributions to plant science research.

Lung chip/Lung on a chip

The microfluidic lung chip/lung on a chip is a miniature experimental platform designed and manufactured based on microfluidics technology to simulate the structure and function of the lungs. It consists of a series of microchannels, chambers, and cell culture membranes, creating a micro-organ that can replicate physiological and pathological processes such as respiratory movements, oxygen and carbon dioxide exchange, and immune responses in the lungs. By introducing different types of cells, viruses, bacteria, and drugs into the chip, it is possible to simulate lung diseases and conduct drug screening.

Engineered Heart Tissue Chips

Heart disease has consistently been a major global health concern, and the research and screening of drugs are crucial for treating these conditions. In recent years, an innovative technology called Engineered Heart Tissue Chips (organ on a chip, microfluidic chips) has garnered widespread attention. This technology utilizes Engineered Heart Tissue (EHT) to create a unique drug screening platform, simulating the three-dimensional structure and mechanical responsiveness of real heart tissue, providing researchers with a more realistic and controllable experimental environment. This article will delve into the key features, advantages, and potential applications of Engineered Heart Tissue Chips in the development of cardiac tissue and the pharmaceutical research field.

Microfluidic PEEK Chips/Cell Culture Chips

Many in vitro methods have long been used for high-throughput drug screening or toxicology testing. However, most of the currently available systems are only partial approximations of human biology and therefore have limited predictive power. Indeed, these systems are either based on human cell cultures, which are unable to capture the complexity of cell behavior in a three-dimensional (3D) environment, or on animal tissue fragments, which have...

organoid chip

An advanced organoid chip technology inspired by the concept of organoid chips, it consists of two independent channels that support 2D and 3D cell cultures to mimic physiological environments, especially in studying the effects of fluid shear stress on gene expression in blood vessels.

Sperm sorting chip

Sperm sorting chips are an advanced technological tool designed specifically for reproductive therapy. Their core advantages include efficiently selecting ideal sperm without the need for cumbersome sample preparation, as well as a standardized and streamlined operational process.

Cell Migration Chip

Cell migration refers to the movement of cells in response to migration signals or the detection of concentration gradients of certain substances. During the movement, cells repeatedly extend protrusions or pseudopodia forward, followed by the retraction of the rear cell body in a cyclical process. The material basis for this process includes the cell cytoskeleton, associated proteins, and the cell matrix. Additionally, various substances intricately regulate this process.

Cell Culture Chip

Cell culture microarrays, also known as cell chips or microfluidic cell culture chips, are an innovative tool in the field of cell biology that is changing the landscape of cell research and medical applications in unprecedented ways. This article will describe the fundamentals of cell culture microarrays, their application areas, and their potential impact in research and medicine.

SpectroCHIP Arrays

The Nucleic Acid Mass Spectrometry Chip (SpectroCHIP Array) is an advanced biochip technology primarily applied in genomics research and DNA sequencing. This chip features highly integrated functions, enabling simultaneous gene sequencing of multiple DNA samples on a single chip. Utilizing high-throughput optical detection technology allows efficient and precise analysis of DNA fragments

Spiral Cell Sorting Chip

The Spiral Cell Sorting Chip is an innovative forefront microfluidic technology. Its unique design incorporates a spiral-shaped microchannel, enabling efficient continuous separation of suspended particles or cells by adjusting fluid velocity and spiral structure. This technology, renowned for its outstanding sorting efficiency, compact device size, and flexibility, finds extensive applications in cell sorting, particle separation, and biomedical research. This article delves into the principles, design features, and application areas of the Spiral Sorting Chip, with a particular focus on its significance in capturing circulating tumor cells (CTCs) for cancer research.

Cell Capture Chip

Cell capture chips represent an advanced application of microfluidic technology widely employed in biomedical research, medical diagnostics, and life sciences. This technology achieves efficient capture, positioning, and analysis of cells through intricate fluidic channels and functional surface structures. This article provides a detailed overview of the principles, application areas, advantages, and future trends of cell capture chips.

DLD Cell Sorting Chip

The continuous advancement of microfluidic technology has propelled the development of the biosensor field. Among these innovations, the DLD (Determination of Leukocyte Deformability) cell sorting chip has emerged as a groundbreaking technology, introducing new possibilities in the realm of cell sorting. This article aims to provide a detailed overview of the principles, advantages, application domains, and future trends of the DLD cell sorter.

electric field cell sorting chip

The electric field cell sorting chip is a microfluidic chip that utilizes the action of an electric field on charged particles to achieve efficient and rapid sorting of particles in a sample. By establishing an electric field within the chip, charged particles generate electric field forces under the influence of the electric field, propelling their migration along the direction of the electric field within the chip. This sorting technology finds wide applications in biomedical research, particle analysis, and more, enabling selective sorting of different particles. The electric field sorting chip offers advantages such as high precision, real-time processing, and high throughput, making it a flexible and effective means for the rapid sorting of microparticles.

Electrophoresis chip

The Electrophoresis Microfluidic Chip is an innovative bioanalytical tool that combines electrophoresis and microfluidic technologies. Integrating the advantages of microfluidics, this technology utilizes micro-scale channels, electric fields, and highly flexible flow control to achieve efficient separation, detection, and analysis of biomolecules. This article delves into the technical principles, application areas, advantages, challenges, and future prospects of CEMC.

droplet chip

Droplet Microfluidics is a microfluidic technology that manipulates and controls liquid droplets at the micrometer scale for various biological and chemical experiments. Integrating knowledge from microfluidics, chemical analysis, and biology, this technology offers advantages such as high integration, automation, high throughput, and low cost, opening new possibilities in laboratory research and clinical diagnostics. In this article, we will provide a detailed overview of the basic principles, applications, advantages, and challenges of droplet microfluidic chips.

Step Emulsification Chip

The Step-Emulsification Chip is a microfluidic chip technology widely used in droplet microfluidics. Utilizing advanced emulsification techniques, it creates a step-like structure through layered formation, allowing efficient control and precise manipulation of droplets. This article delves into the technical principles, fabrication methods, application areas, advantages, challenges, and future prospects of Step-Emulsification Chips.

RNA Analysis Chip (No Amplification)

In the ever-evolving field of biomedical technology, the single-molecule RNA analysis chip (amplification-free) has emerged as an advanced tool for biological analysis, garnering widespread attention. In comparison to traditional RNA analysis methods, the unique feature of no amplification and the high sensitivity to individual RNA molecules offer novel possibilities for early disease diagnosis and treatment. This article delves into the technical principles, application areas, advantages, challenges, and future prospects of the single-molecule RNA analysis chip.

Drop-seq chip

Microfluidic droplet sequencing chip is an advanced biochip that combines microfluidic technology with high-throughput sequencing technology. Its core principle involves creating tiny droplets within the chip through microfluidics, where each droplet serves as a microreactor, enabling large-scale, high-throughput genetic sequencing on a single chip.

Organ chip processing equipment

In today's biomedical research field, organoid chip/cell culture chip/organ-on-a-chip technology is pushing the boundaries of science at an astonishing pace. To achieve more realistic and efficient biological experiments, equipment for the processing of organoid chips, cell culture chips, and organ-on-a-chip has become an indispensable key element. TopSun Microcontrol has introduced a series of advanced equipment, including desktop photolithography machines, spin coaters, developers, PDMS chip processing equipment, plasma bonders, providing comprehensive support for the advancement of organoid chip technology and cell culture chip technology.

Photolithography Machine/Exposure System

Dxfluidics Desktop Micro Lithography Machine is designed for the fabrication of micrometer-scale patterns, ensuring excellent pattern transfer accuracy. The equipment utilizes a UV LED cold light source, combined with double aspheric quartz lenses, to generate parallel light with a semi-angle of <2°. Compared to traditional contact exposure machines, its extremely compact size places it on the desktop, providing convenience and precision in operation.

SU-8 Mold Processing Platform

SU-8 Mold Processing Platform is designed to provide an efficient and comprehensive solution for SU-8 mold processing. The platform integrates core equipment, including a desktop photolithography machine, spin coater, and hotplate. The desktop photolithography machine is compact, using LED light sources with an exposure resolution of up to 2um and exposure uniformity exceeding 90%, allowing for the precise fabrication of micro/nano structures. The spin coater has stable rotation speed...

PBESR-PRO-500

The PulseBlasterESR-PRO™ is a high-speed intelligent pulse/pattern/delay generator designed to output precisely timed TTL patterns.The PulseBlasterESR-PRO derives its intelligence from an embedded microprogramming controller core nicknamed “PulseBlasterESR-PRO “.

syringe pump

A syringe pump is a device for controlling precise liquid flow and flow rate based on a stepper motor as a drive source. It typically consists of a stepper motor, a pump head and a controller. The stepper motor provides precise speed and position control, the pump head is used to push the liquid into the line, and the controller controls the angle and speed of motor rotation.

PDMS Chip Processing Equipment

The PDMS Chip Processing Platform is designed to provide an efficient and comprehensive solution for the preparation of PDMS chips. This platform integrates electronic scales, PDMS chip pouring devices, ovens, PDMS chip punching machines, PDMS chip cutting tools, PDMS chip aligners, as well as PDMS plasma bonding machines and other PDMS chip processing equipment.

Hot Press Bonding Machine

The Hot Press Bonding Machine designed for the preparation of microfluidic chips is specifically used for bonding plastic chips (such as PMMA, PC, COC, etc.) to achieve chip encapsulation and integration. This bonding machine employs vacuum hot press technology, characterized by high efficiency, precision, and reliability, making it suitable for various packaging and integration requirements.

Plasma Surface Treated Slides

Dingxu Bio is a high-tech enterprise focusing on surface modification of materials, dedicated to providing customized surface modification services for various substrates (e.g. glass, polymers, etc.). Our technologies cover surface hydrophobicity, hydrophilicity, and modification of various functional groups (e.g., amino groups, aldehyde groups, epoxy groups, etc.). Through these modification technologies, we are able to significantly enhance the performance and adaptability of materials to meet the diverse needs of biomedical, electronic technology, aerospace and industrial manufacturing.

microtiter plate

Microtiter plate is a laboratory tool widely used in high throughput screening (HTS), enzyme-linked immunosorbent assay (ELISA), cell culture, nucleic acid and protein assays (PCR, qPCR) and so on. Common specifications include 6-well, 24-well and 96-well, and the materials are mainly polystyrene and polypropylene. According to the experimental needs, choosing microtiter plates with different numbers of wells, volumes and surface treatments can significantly improve the experimental efficiency and data reliability.

Microfluidic surface treatment reagents

Fluorine oil, as a perfluoroalkane compound, is widely used as the continuous phase of water-in-oil droplets because of its low viscosity, high boiling point and good biocompatibility. What's more, according to the principle of similar solubility, fluorine oil is immiscible with hydrocarbon alkyl compounds, so fluorine oil, as a continuous phase, can be used to prepare not only water-in-oil droplets, but also acetonitrile-in-fluorine oil, DMF-in-fluorine oil, and methylene fluoride-in-fluorine oil...

Silicon

Silicon wafer plays an indispensable role in microfluidic chip fabrication and can be used to prepare SU8 molds, silicon molds, and silicon runner chips. SU-8 mold Silicon wafers are widely used in SU-8 mold preparation.SU-8 photoresist is a polymer material with excellent mechanical properties and chemical stability, which can be used to fabricate microchannels and microjunctions in microfluidic chip...

PMMA/PC/COC

Microfluidic chips utilize micromachining techniques to process tiny channels and microstructures onto micron-scale material surfaces to enable microfluidic control and manipulation. Common microfluidic chip polymer (plastic) materials include COC cyclic olefin polymers, PMMA and PC materials.

SU-8 photoresist/developer solution

SU-8 photoresist is a high-resolution, high-precision, high-adhesion negative photoresist, which is widely used in the field of micro and nanofabrication. In microfluidic chips, SU-8 photoresist is widely used in the preparation of microfluidic chips, which can be used to prepare microstructures such as microfluidic channels, reaction chambers, valves and pumps.

Glass materials

Microfluidic chips are miniaturized laboratory systems for controlling and manipulating tiny liquid fluids. Among other things, the material of the chip is crucial as it can directly affect the performance and stability of the chip. One of the commonly used materials for microfluidic chips is glass. Glass has many advantages, such as excellent chemical stability, transparency, high temperature stability, and corrosion resistance. In addition, ...

PDMS/PDMS Film/PDMS Microporous Film

PDMS (polydimethylsiloxane) PDMS is a commonly used material for microfluidic chips, and its full name is polydimethylsiloxane.PDMS has the following advantages, which make it a commonly used material in microfluidic chip preparation: In conclusion, PDMS is one of the commonly used materials in microfluidic chip preparation, with good transparency, biocompatibility, flexibility and plasticity. ...

Lipid Nanoparticle Synthesis Chip

The Lipid Nanoparticle Chip (LNP Chip) is an advanced technology widely used in the field of nanotechnology. It is designed based on the unique structure of lipid nanoparticles to achieve efficient drug delivery and biomedical research. This article will delve into the principles, structural design, performance characteristics, and applications in drug delivery and biomedical research of the Lipid Nanoparticle Chip.

Staggered Herringbone Micromixer Chip

The Staggered Herringbone Micromixer Chip (SHM) integrates microfluidics with the unique structure of staggered herringbone, showcasing excellent mixing and separation performance. Its distinctive channel layout emulates the bifurcated structure of a herringbone, effectively increasing mixing pathways and enhancing mixing efficiency.

Micromixer chip

With the continuous development of microfluidic technology, the micro-mixing microfluidic chip, as one of its important applications, is increasingly attracting widespread attention. This article will delve into the fundamental concepts, principles, structural design, performance characteristics, and extensive applications of micro-mixing microfluidic chips in different fields.

Concentration Gradient Chip

Concentration gradient chip is a microfluidic chip technology that operates on a small scale to create and manipulate concentration gradients in solutions. This technology finds widespread applications across various fields, providing a powerful tool for laboratory research and clinical diagnostics. This overview delves into the fundamental principles, design structure, application areas, and future directions of concentration gradient chips.

Fractured Rock Core Chip

裂隙岩体芯片是一项先进的微流体技术，旨在模拟裂隙岩体中的流体运移过程。这一创新的实验平台不仅在地质学领域引起了广泛关注，而且在石油工程、水资源管理等领域也展现出巨大的潜力。本文将对裂隙岩体芯片进行深入探讨，包括其技术原理、制造材料、裂隙…

Array Permeation Chip

Array Permeation Chip is a cutting-edge technology that has garnered widespread attention in the fields of biology, chemistry, and medicine, providing an innovative tool for laboratory research. This article will delve into the principles, design features, application areas, and potential impact of the Array Permeation Chip in scientific research.

Customized Processing

Customized Processing Services

Microfluidic Chip Injection Molding for Mass Production

Microfluidic plastic chips are an innovative technology for fluid manipulation and analysis at the microscale, widely applied in biomedical, chemical analysis, and laboratory research fields. To achieve mass production of these microchips, injection molding technology is extensively employed, providing an efficient, precise, and cost-effective solution for their manufacturing.

Microfluidic Plastic Chips

Microfluidic plastic chips are miniature laboratory devices made from polymer materials, featuring microchannels and microchambers for controlling and analyzing microfluids. In comparison to traditional glass chips, plastic chips offer advantages such as low cost, flexible fabrication, lightweight, and easy processing. Widely applied in biomedical research, chemical analysis, environmental monitoring, etc., these chips enable effective experiments like micro-reactions, cell culture, drug screening, providing convenient tools for laboratory research. Microfluidic plastic chips play a crucial role in advancing microfluidic technology, promoting automation, and high-throughput experiments in laboratories.

Microfluidic glass chip

Glass chips are essential tools in microfluidic technology, utilizing glass as the material for chip fabrication. In comparison to traditional polymer chips, glass chips exhibit outstanding optical transparency, chemical inertness, thermal stability, and biocompatibility. These characteristics make glass chips widely applicable in fields such as life science research, medical diagnostics, and drug screening.

Microfluidic chip made of PDMS

PDMS, short for polydimethylsiloxane, is a common organic polymer used in the fabrication of prototypes for microfluidic chips. It possesses properties such as elasticity, transparency, breathability, and chemical inertness. PDMS is suitable for chip manufacturing applications related to cell culture, drug screening, and cell capture. Being inherently hydrophobic, its surface can be modified chemically or physically.

Microfluidic chip 3D printing

Microfluidic chip (Microfluidic chip) is a kind of micro-laboratory that processes and analyzes fluids through micro-channels within the micron scale. It has the advantages of handling micro-volume samples, rapid response, low cost, and integrability, and thus has been widely used in biomedical and chemical analysis fields. The fabrication process of microfluidic chips involves a variety of technologies, among which 3D printing is one of the widely used technologies.

biometrics chip

The QR code is etched on the microfluidic chip or other chips, which is used to identify the chip information and facilitate the tracking of the whole process during the experiment.

microfluidic metal chip

Microfluidic metal chips are suitable for applications with fast heat transfer, high pressure tolerance and high conductivity, and are commonly used in high-temperature/high-pressure microreactors and electrochemical flow cells.

Surface modification/modification

Low Pressure Plasma Coating Technology is a technology that generates plasma in a low-pressure vacuum environment to activate the surface of the substrate. At the same time, a gas mixture or evaporated liquid monomer is used as the raw material for the coating, which is introduced into the vacuum process chamber, and then adhered to the surface of the substrate and covalently bonded with it in a plasma atmosphere, to form a dense, high-quality coating with a thickness ranging from 10 nanometers to 100 micrometers.

Surface modification/modification - PEG modification

PEG modification of a biochip surface is a surface modification method that introduces polyethylene glycol (PEG) functional groups to the surface of a biochip.PEG modification can be used to alter the chemical and physical properties of the chip surface to achieve specific application requirements.PEG modification is usually carried out by a chemical reaction that combines the PEG molecules with the surface of the chip to form a stable PEG layer. PEG modification is usually achieved by chemically binding PEG molecules to the chip surface to form a stable PEG layer.

Surface modification/modification - epoxy group modification

Surface epoxy group modification of biochips (or gene chips) is a commonly used surface functionalization method for introducing epoxy group (-O-CH2-CH2-O-) functional groups on the chip surface. This modification allows for the immobilization, detection and analysis of specific biomolecules through a series of chemical reactions that form reactive groups on the chip surface that can chemically react with other molecules.

Surface modification/modification - aldolization modification

Aldehyde-based modification of biochip surfaces is a commonly used surface functionalization method for introducing aldehyde (-CHO) functional groups on the surface of biochips. This modification allows for the immobilization and detection of specific biomolecules through a series of chemical reactions that form reactive groups on the surface of the biochip that can chemically react with other molecules.

Surface Modification/Modification - Amino Modification

Amino modification of biochip surfaces is a common modification method that imparts certain chemical activity and affinity to the surface by introducing amino groups to the surface. Amino modification can be used for applications such as control of surface chemistry, functionalization, and immobilization and detection of biomolecules.

Surface modification/modification - long-lasting hydrophobic treatment

The hydrophobic treatment of biochip surface is to make the surface hydrophobic by introducing hydrophobic modifier or changing the surface chemistry, so as to realize the effect of anti-sorption and anti-pollution to water or aqueous liquid. The following are some common hydrophobic treatment methods for biochip surfaces:

Surface modification/modification - long-lasting hydrophilic treatment

Hydrophilic modification of the surface of biochips is to make the surface hydrophilic by introducing hydrophilic modifiers or changing the surface chemistry, so as to realize the adsorption and wetting effects on water or aqueous liquids. Hydrophilic modification can facilitate the interaction of biochips with aqueous liquids, which is beneficial for applications such as molecular recognition, cell culture and fluid manipulation. The following are some common methods of hydrophilic modification of biochip surfaces:

PMMA Molds/Aluminum Molds

PDMS is the primary material used in the fabrication of microfluidic chips, with the main method being replica molding. Replica molding necessitates well-formed, plastic-molded PDMS chip molds. PMMA molds and aluminum molds, manufactured using mechanical processing methods, are advantageous for producing large-sized, high aspect ratio channels. They exhibit greater strength compared to silicon and SU8 molds, can be reused multiple times, and offer a cost-effective solution.

SU-8 Molds/PDMS Chip Molds

SU-8 is a high-resolution negative photoresist known for its outstanding mechanical, dielectric, chemical resistance, and thermal properties, as well as excellent biocompatibility. In the field of microfluidics, it is commonly used to fabricate molds for preparing PDMS microfluidic chips.

Epoxy Resin molds

Epoxy resin material, suitable for casting PDMS chips, combines the precision of SU8 molds with the durability of conventional acrylic molds.

Silicon Molds / PDMS Chip Molds

Silicon molds (PDMS chip molds) are the ideal choice for fabricating high aspect ratio PDMS microchannel structures. Utilizing dry etching techniques on silicon, it is possible to effortlessly achieve microchannels with aspect ratios as high as 25:1, while maintaining controlled line widths of 2 micrometers or more with precision errors within the range of ±1 micrometer. However, silicon surfaces typically exhibit strong hydrophilicity, which may lead to

MEMS Packaging Process

It refers to the process of processing the tested wafers according to the product model and functional requirements to get an independent chip, and the processes involved include: slicing (scribing), patching, leading and bonding.

photolithography

Photolithography is the use of exposure and development techniques to etch the device structure on the photoresist layer, and then the graphics on the mask are converted to the substrate through the etching process. The main photolithography are: electron beam lithography, step lithography, contact lithography and many other photolithography techniques.

Microfluidic chip etching process

The technique of selectively etching or stripping a semiconductor substrate surface or surface-covered film in accordance with the mask pattern or design requirements. Etching technology is not only the basic manufacturing process of semiconductor devices and integrated circuits, but also applied to thin-film circuits, printed circuits and other microfabrication. Etching can also be divided into wet etching and dry etching.

Coating process

Coating is a technique in which a material (commonly known as a target or film) is deposited on the entire surface of a substrate under vacuum conditions using physical bombardment or chemical reaction.